In this section, we focus on the third component of the 4 S framework: “space.” This component relates to the presence or absence of physical structures or constraints that can affect health outcomes. Space presents a double challenge in COVID-19. First, spaces that facilitate social distancing or shelter-in-place are needed, a challenging prospect in some densely populated, lower-income communities. Second, for positive or suspected cases of COVID-19, there must be a dedicated safe facility for diagnosis, treatment, and isolation. These facilities will prevent further community spread and keep providers safe from acquiring or transmitting the infection.